Phosphatidylserine
Phosphatidylserine (PS)
The Brain Cell Membrane Nutrient
Phosphatidylserine is a phospholipid that forms a critical component of cell membranes, particularly in the brain where it makes up about 15% of the phospholipid pool. It's essential for neuronal signaling, neurotransmitter release, and cognitive function. PS levels decline with age, making supplementation valuable for maintaining brain health.

Per Chew
5 mg
Key Benefits
Discover how Phosphatidylserine supports your dog's health and longevity
Brain Cell Membrane Health
Maintains the structural integrity and fluidity of neuronal membranes, essential for proper brain cell function.
Memory & Learning
Supports memory formation, learning ability, and cognitive flexibility by enabling proper neuronal signaling.
Neurotransmitter Support
Facilitates the release of key neurotransmitters including acetylcholine, dopamine, and serotonin.
Stress Response
Helps modulate cortisol response to stress, supporting balanced reactions to challenging situations.
See How Phosphatidylserine Works
Watch this short animation to understand how Phosphatidylserine supports your dog's health at the cellular level

Scientific animation showing the mechanism of action of Phosphatidylserine (PS)
How It Works
Phosphatidylserine is incorporated into neuronal cell membranes where it maintains membrane fluidity and supports the function of membrane-bound proteins. This enables proper neurotransmitter release, receptor function, and cell-to-cell communication. PS also supports glucose uptake into brain cells, ensuring neurons have the energy they need. Additionally, PS helps modulate the cortisol stress response.
Works Best With:
Dosage Information
Timing: Can be given any time of day
Cognitive benefits develop gradually over 4-12 weeks of consistent use.
Safety Profile
Phosphatidylserine has an excellent safety profile with extensive research in both animals and humans. It's a natural component of cell membranes and is found in foods like soybeans and egg yolks. No significant adverse effects have been reported at supplemental doses.
Research & Citations
Scientific studies supporting the benefits of Phosphatidylserine
The Effects of Phosphatidylserine on Age-Associated Memory Impairment
Crook TH, Tinklenberg J, Yesavage J, et al.
Neurology, 1991
Clinical trial demonstrating PS improved memory in subjects with age-related cognitive decline.
Phosphatidylserine in the Brain: Metabolism and Function
Glade MJ, Smith K
Nutrition, 2015
Comprehensive review of PS's role in brain function and cognitive health.
View StudyEffects of Phosphatidylserine on Memory Function in Elderly Japanese Subjects with Memory Complaints
Kato-Kataoka A, Sakai M, Ebina R, et al.
Journal of Clinical Biochemistry and Nutrition, 2010
Showed PS supplementation improved memory and cognitive function.
View StudyLearn More About Phosphatidylserine
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