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Brain & Focus

Phosphatidylserine

Phosphatidylserine (PS)

The Brain Cell Membrane Nutrient

Phosphatidylserine is a phospholipid that forms a critical component of cell membranes, particularly in the brain where it makes up about 15% of the phospholipid pool. It's essential for neuronal signaling, neurotransmitter release, and cognitive function. PS levels decline with age, making supplementation valuable for maintaining brain health.

Makes up about 15% of the brain's phospholipid pool
Essential for neurotransmitter release and receptor function
Levels decline with age, contributing to cognitive changes
FDA-qualified health claim for cognitive function
Phosphatidylserine

Per Chew

5 mg

Key Benefits

Discover how Phosphatidylserine supports your dog's health and longevity

Brain Cell Membrane Health

Maintains the structural integrity and fluidity of neuronal membranes, essential for proper brain cell function.

Memory & Learning

Supports memory formation, learning ability, and cognitive flexibility by enabling proper neuronal signaling.

Neurotransmitter Support

Facilitates the release of key neurotransmitters including acetylcholine, dopamine, and serotonin.

Stress Response

Helps modulate cortisol response to stress, supporting balanced reactions to challenging situations.

Watch & Learn

See How Phosphatidylserine Works

Watch this short animation to understand how Phosphatidylserine supports your dog's health at the cellular level

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Click to play

Scientific animation showing the mechanism of action of Phosphatidylserine (PS)

How It Works

Phosphatidylserine is incorporated into neuronal cell membranes where it maintains membrane fluidity and supports the function of membrane-bound proteins. This enables proper neurotransmitter release, receptor function, and cell-to-cell communication. PS also supports glucose uptake into brain cells, ensuring neurons have the energy they need. Additionally, PS helps modulate the cortisol stress response.

Works Best With:

DHA (another membrane component)
Lion's Mane (NGF stimulation)
Alpha-GPC (choline for acetylcholine)

Dosage Information

Per Chew5 mg
Small Dogs (<25 lbs)5 mg (1 chew)
Medium Dogs (25-50 lbs)10 mg (2 chews)
Large Dogs (>50 lbs)15 mg (3 chews)

Timing: Can be given any time of day

Cognitive benefits develop gradually over 4-12 weeks of consistent use.

Safety Profile

Phosphatidylserine has an excellent safety profile with extensive research in both animals and humans. It's a natural component of cell membranes and is found in foods like soybeans and egg yolks. No significant adverse effects have been reported at supplemental doses.

Research & Citations

Scientific studies supporting the benefits of Phosphatidylserine

The Effects of Phosphatidylserine on Age-Associated Memory Impairment

Crook TH, Tinklenberg J, Yesavage J, et al.

Neurology, 1991

Clinical trial demonstrating PS improved memory in subjects with age-related cognitive decline.

Phosphatidylserine in the Brain: Metabolism and Function

Glade MJ, Smith K

Nutrition, 2015

Comprehensive review of PS's role in brain function and cognitive health.

View Study

Effects of Phosphatidylserine on Memory Function in Elderly Japanese Subjects with Memory Complaints

Kato-Kataoka A, Sakai M, Ebina R, et al.

Journal of Clinical Biochemistry and Nutrition, 2010

Showed PS supplementation improved memory and cognitive function.

View Study

Give Your Dog the Gift of Longevity

Phosphatidylserine is just one of the powerful ingredients in Pawdagen's comprehensive longevity formula.