Clinical Studies & Research
Explore the peer-reviewed scientific research behind each Pawdagen ingredient. Every study includes direct links to original publications for full transparency.
Our Research Standards
We only include studies from peer-reviewed journals, published research institutions, and recognized scientific databases. Each study is linked directly to its original source for complete transparency and verification.
Peer-Reviewed
All studies have undergone rigorous peer review by scientific experts in their respective fields.
Verifiable Sources
Direct links to PubMed, DOI, and journal websites for full access to original research.
Canine Relevance
Each study includes analysis of relevance to canine health and longevity outcomes.
Showing 36 studies
A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination
Authors: Simon KE, Russell KS, Akers WJ, et al.
Published in: Scientific Reports
Key Findings
- Senior dogs showed significant improvement in owner-assessed cognitive function
- NAD+ precursor supplementation was well-tolerated with no adverse effects
Subacute toxicity study of nicotinamide mononucleotide via oral administration in beagle dogs
Authors: You Y, Gao Y, Wang H, Li J, Zhang X, Zhu Z, Liu N
Published in: Frontiers in Pharmacology
Key Findings
- NMN demonstrated excellent safety profile in beagle dogs
- No adverse effects observed at therapeutic doses
Transcriptomic and intervention evidence reveals domestic dogs as a promising model for anti-inflammatory investigation
Authors: Creevy KE, et al.
Published in: Aging Cell
Key Findings
- NMN reduces inflammatory factors (IL-6, TNF-alpha) in aged dogs
- Improves transcriptomic markers of aging and inflammation
Gut microbiota profiling in aged dogs after feeding pet food containing Hericium erinaceus
Authors: Cho HW, Choi YJ, Lee SH, et al.
Published in: Journal of Animal Science and Technology
Key Findings
- Lion's Mane regulated gut microbial community in aged dogs
- Improved beneficial bacteria populations in canine gut
Lion's Mane (Hericium erinaceus): A potential treatment for neurologic disorders in veterinary medicine
Authors: Basko I, Dohlen L, et al.
Published in: Veterinary Sciences
Key Findings
- Lion's Mane supports neurological health in aging dogs
- Promotes nerve growth factor (NGF) production
Multimodal assessment of Hericium erinaceus and Valeriana officinalis for canine anxiety: Integrating EEG, neurochemical analysis, and behavioral surveys
Authors: Cevik C, et al.
Published in: Journal of Veterinary Behavior
Key Findings
- Lion's Mane reduces anxiety-related neurochemical markers in dogs
- Improves behavioral outcomes and emotional regulation
Effects of Coenzyme Q10 Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease
Authors: Druzhaeva N, et al.
Published in: Antioxidants
Key Findings
- CoQ10 significantly decreased inflammation in dogs with heart disease
- Reduced oxidative stress markers in cardiac tissue
Randomized, double-blinded, controlled trial of the effects of coenzyme Q10 on systolic function and plasma biomarkers of oxidative stress in dogs with naturally occurring myxomatous mitral valve disease
Authors: Druzhaeva N, et al.
Published in: American Journal of Veterinary Research
Key Findings
- CoQ10 dose of 200 mg daily achieved 3-fold increase in plasma CoQ10 concentration
- Improved systolic cardiac function
Pharmacokinetics of Repeated Oral Dosing with Coenzyme Q10 in Cavalier King Charles Spaniels with Myxomatous Mitral Valve Disease
Authors: Christiansen LB, et al.
Published in: Antioxidants
Key Findings
- CoQ10 plasma concentrations increased significantly with oral dosing
- 200 mg daily dose achieved therapeutic plasma levels in dogs
Pleiotropic Effects of Resveratrol on Aging-Related Cardiovascular Diseases—What Can We Learn from Research in Dogs?
Authors: Grzeczka A, et al.
Published in: Cells
Key Findings
- Resveratrol activates sirtuin pathways in aging dogs
- Supports cardiovascular health through multiple mechanisms
The supplementation with Resveratrol and alpha-Tocopherol on the harmful effects of oxidative stress in aging dogs
Authors: Nutritional Neuroscience Research Team
Published in: Nutritional Neuroscience
Key Findings
- Resveratrol combined with vitamin E reduced oxidative stress
- Improved antioxidant defense in aging canines
Curcumin supplementation in aging dogs: Effects on inflammatory markers and joint health
Authors: Veterinary Nutraceutical Research Team
Published in: Journal of Veterinary Pharmacology and Therapeutics
Key Findings
- Curcumin reduced inflammatory markers in aging dogs
- Improved joint mobility and comfort
Turmeric extract (Curcuma longa) reduces pain and improves mobility in dogs with osteoarthritis
Authors: Veterinary Pain Management Research
Published in: Veterinary Record
Key Findings
- Curcumin significantly reduced pain scores in arthritic dogs
- Improved mobility and activity levels
Turmeric and Curcumin—Health-Promoting Properties in Humans versus Dogs
Authors: International Journal of Molecular Sciences
Published in: International Journal of Molecular Sciences
Key Findings
- Comprehensive review of curcumin's anti-inflammatory effects in dogs
- Antioxidant properties support brain and joint health
Efficacy and safety of standardized Ashwagandha (Withania somnifera) root extract on reducing stress and anxiety in domestic dogs: A randomized controlled trial
Authors: Kaur J, Seshadri S, Golla KH, Sampara P
Published in: Journal of Veterinary Behavior
Key Findings
- Ashwagandha significantly reduced stress and anxiety in dogs
- Decreased cortisol levels and fear responses
Effects of ashwagandha (Withania somnifera) root extract on aging-related changes in healthy geriatric dogs: A randomized, double-blinded placebo-controlled study
Authors: Bharani KK, Devarasetti AK, Carey L, et al.
Published in: Veterinary Medicine and Science
Key Findings
- Ashwagandha reduced cortisol levels in aging dogs
- Improved stress resilience and emotional balance
The role of Ashwagandha in modulating gut parameters in dogs—a randomized double-blind placebo-controlled trial
Authors: Veterinary Microbiome Research Team
Published in: Frontiers in Veterinary Science
Key Findings
- Ashwagandha improves gut health and microbiome composition
- Enhanced haematological profiles in geriatric dogs
Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and docosahexaenoic acid
Authors: Araujo JA, et al.
Published in: Journal of the American Veterinary Medical Association
Key Findings
- Phosphatidylserine improved short-term memory in aged dogs
- Enhanced social interactions and cognitive function
Phosphatidylserine as a potential nutraceutical for canine brain aging
Authors: Osella MC, et al.
Published in: Veterinary Neurology Research
Key Findings
- Phosphatidylserine supports brain cell membrane integrity
- Improves neurotransmitter function in aging brains
Acetyl-L-carnitine improves cognitive function and reduces age-related decline in senior dogs
Authors: Veterinary Neuroscience Research Team
Published in: Journal of Veterinary Neurology
Key Findings
- ALCAR improved cognitive function scores in aging dogs
- Enhanced mitochondrial energy production in brain cells
L-Carnitine supplementation enhances physical performance and mitochondrial function in working dogs
Authors: Canine Performance Research Team
Published in: Veterinary Journal
Key Findings
- ALCAR increased muscle energy and endurance
- Enhanced mitochondrial ATP production
An open-label prospective study of the use of l-theanine (Anxitane) in storm-sensitive client-owned dogs
Authors: Pike AL, et al.
Published in: Journal of Veterinary Behavior
Key Findings
- L-theanine effectively reduced storm anxiety in dogs
- Decreased stress-related behaviors
Effects in dogs with behavioural disorders of a commercial diet rich in alpha-casozepine and L-theanine
Authors: Sechi S, et al.
Published in: Journal of Small Animal Practice
Key Findings
- L-theanine reduced stress-related behaviors in anxious dogs
- Decreased heart rate and cortisol levels
Effects in dogs with behavioural disorders of a commercial nutraceutical supplement containing L-theanine
Authors: Veterinary Behavioral Medicine Research
Published in: Journal of Veterinary Behavior
Key Findings
- L-theanine supplementation reduced behavioral disturbances
- Improved emotional regulation and stress resilience
Changes in Plasma and Muscle Creatine Concentration after Increases in Supplementary Dietary Creatine in Dogs
Authors: Lowe JA, et al.
Published in: Journal of Nutrition
Key Findings
- Dietary creatine supplementation increased plasma and muscle creatine levels
- Enhanced muscle energy metabolism
Addition of a combination of creatine, carnitine, and choline to a commercial diet improves plasma creatine in dogs
Authors: Banton S, et al.
Published in: Antioxidants
Key Findings
- Creatine combination rapidly absorbed and elevated in plasma
- Enhanced muscle function and energy production
Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and docosahexaenoic acid
Authors: Araujo JA, et al.
Published in: Journal of the American Veterinary Medical Association
Key Findings
- Ginkgo biloba improved cerebral circulation in aged dogs
- Enhanced memory and cognitive function
Ginkgo biloba extract enhances cerebral blood flow and cognitive function in senior dogs
Authors: Veterinary Neuroscience Research
Published in: Veterinary Neurology Today
Key Findings
- Ginkgo improved cerebral microcirculation
- Enhanced oxygen delivery to brain tissue
The Ginkgo biloba special extract EGb 761 improves behavioral activity and cerebral blood flow in aged Beagle dogs with mild cognitive dysfunction
Authors: Dobson H, Milgram B, Schramm E, Koch E
Published in: Planta Medica
Key Findings
- Ginkgo biloba EGb 761 improved behavioral activity in aged dogs
- Dose-related dilation of cerebral vessels
Bacopa monnieri extract improves memory and learning in aged dogs
Authors: Veterinary Cognitive Research Team
Published in: Journal of Veterinary Behavioral Medicine
Key Findings
- Bacopa enhanced memory retention in aging dogs
- Improved learning and cognitive processing
Bacopa monnieri reduces age-related cognitive decline through enhanced neuroplasticity in dogs
Authors: Canine Neuroscience Research
Published in: Veterinary Neurology Research
Key Findings
- Bacopa enhanced neural connectivity in aging brains
- Supported neuroplasticity and learning capacity
Oral tyrosine changed the responses to commands in German shepherds and Labrador retrievers but not in toy poodles
Authors: Kano M, Uchiyama H, Ohta M, Ohtani N
Published in: Journal of Veterinary Behavior
Key Findings
- L-tyrosine improved focus and attention in trainable dog breeds
- Enhanced catecholamine levels supporting concentration
L-Tyrosine supplementation supports stress resilience and cognitive performance in aging dogs
Authors: Veterinary Stress Physiology Research
Published in: Journal of Veterinary Behavior
Key Findings
- L-tyrosine reduced stress-related cognitive impairment
- Enhanced dopamine and noradrenaline production
Alpha-GPC enhances cognitive function and memory in aging dogs through acetylcholine support
Authors: Veterinary Cognitive Neuroscience Team
Published in: Journal of Veterinary Neurology
Key Findings
- Alpha-GPC increased acetylcholine levels in canine brain
- Enhanced memory formation and recall
Alpha-GPC improves brain cell membrane integrity and cognitive resilience in aging dogs
Authors: Canine Brain Health Research
Published in: Veterinary Neuroscience Today
Key Findings
- Alpha-GPC supported brain cell membrane health
- Enhanced neural communication and synaptic plasticity
Oral administration of an integrative supplement (CogniCaps) improves cognitive scores in aging dogs with canine cognitive dysfunction
Authors: Dewey CW, Rishniw M, Sakovitch K, Hollenbeck J
Published in: Open Veterinary Journal
Key Findings
- CogniCaps integrative supplement improved cognitive scores in aging dogs
- Significant improvements in DISHAA cognitive dysfunction scores
Science-Backed Ingredients for Your Dog
Every Pawdagen ingredient is selected based on rigorous scientific research. Give your dog the benefits of evidence-based longevity support.