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Cellular Vitality

Resveratrol

Trans-Resveratrol

The Longevity Activator

Resveratrol is a powerful polyphenol found in red grapes, berries, and peanuts. It gained fame for its ability to activate sirtuins—proteins often called 'longevity genes' that regulate cellular health, metabolism, and stress resistance. Resveratrol mimics some effects of caloric restriction, one of the most robust interventions known to extend lifespan.

Activates the same pathways as caloric restriction
Works synergistically with NMN for enhanced sirtuin activation
Trans-resveratrol is the most bioactive form
Found naturally in red grapes, berries, and peanuts
Resveratrol

Per Chew

5 mg

Key Benefits

Discover how Resveratrol supports your dog's health and longevity

Sirtuin Activation

Activates SIRT1 and other sirtuins, triggering cellular pathways associated with longevity, DNA repair, and metabolic health.

Powerful Antioxidant

Neutralizes free radicals and enhances the body's own antioxidant systems, providing comprehensive cellular protection.

Cardiovascular Support

Supports healthy blood vessel function, blood flow, and cardiovascular health through multiple mechanisms.

Healthy Inflammatory Response

Modulates inflammatory pathways, supporting balanced inflammation and tissue health throughout the body.

Watch & Learn

See How Resveratrol Works

Watch this short animation to understand how Resveratrol supports your dog's health at the cellular level

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Scientific animation showing the mechanism of action of Trans-Resveratrol

How It Works

Resveratrol activates sirtuins, particularly SIRT1, which regulate DNA repair, metabolism, and cellular stress responses. This mimics some benefits of caloric restriction without reducing food intake. Resveratrol also works as a direct antioxidant and enhances the body's endogenous antioxidant systems (glutathione, SOD, catalase). It accumulates in tissues including the brain, providing systemic protection.

Works Best With:

NMN (provides NAD+ for sirtuin function)
Curcumin (complementary antioxidant)
CoQ10 (mitochondrial protection)

Dosage Information

Per Chew5 mg
Small Dogs (<25 lbs)5 mg (1 chew)
Medium Dogs (25-50 lbs)10 mg (2 chews)
Large Dogs (>50 lbs)15 mg (3 chews)

Timing: Can be given any time, with or without food

Works synergistically with NMN—resveratrol activates sirtuins while NMN provides the NAD+ they need to function.

Safety Profile

Resveratrol has been extensively studied and is well-tolerated. It's naturally present in foods like grapes and berries. No significant adverse effects have been reported at supplemental doses. Trans-resveratrol is the most bioactive and studied form.

Research & Citations

Scientific studies supporting the benefits of Resveratrol

Resveratrol Improves Health and Survival of Mice on a High-Calorie Diet

Baur JA, Pearson KJ, Price NL, et al.

Nature, 2006

Landmark study showing resveratrol's protective effects and sirtuin activation.

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Small Molecule Activators of Sirtuins Extend Saccharomyces cerevisiae Lifespan

Howitz KT, Bitterman KJ, Cohen HY, et al.

Nature, 2003

Foundational research identifying resveratrol as a sirtuin activator.

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Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

Pearson KJ, Baur JA, Lewis KN, et al.

Cell Metabolism, 2008

Demonstrated resveratrol's ability to mimic caloric restriction benefits.

View Study

Give Your Dog the Gift of Longevity

Resveratrol is just one of the powerful ingredients in Pawdagen's comprehensive longevity formula.