Cellular Vitality

NMN

Nicotinamide Mononucleotide

The Cellular Energy Molecule

NMN is a direct precursor to NAD+, a critical coenzyme found in every living cell. NAD+ levels decline significantly with age, leading to reduced cellular energy, impaired DNA repair, and accelerated aging. NMN supplementation helps restore youthful NAD+ levels, supporting cellular vitality and healthy aging pathways.

NAD+ levels can decline by 50% or more by senior years
NMN is a direct precursor—the most efficient way to boost NAD+
Supports over 500 enzymatic reactions in the body
Benefits typically noticed within 2-4 weeks of consistent use
NMN

Per Chew

25 mg

Key Benefits

Discover how NMN supports your dog's health and longevity

Cellular Energy Production

Boosts NAD+ levels to support mitochondrial function and ATP production, providing sustained energy for every cell in your dog's body.

DNA Repair Support

NAD+ is essential for PARP enzymes that repair damaged DNA, helping maintain genomic stability and cellular health.

Sirtuin Activation

Activates sirtuins—the 'longevity genes'—which regulate metabolism, stress resistance, and healthy aging pathways.

Cognitive Function

Supports brain cell energy and neuronal health, helping maintain mental clarity and cognitive function as dogs age.

Watch & Learn

See How NMN Works

Watch this short animation to understand how NMN supports your dog's health at the cellular level

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Scientific animation showing the mechanism of action of Nicotinamide Mononucleotide

How It Works

When your dog consumes NMN, it's efficiently absorbed in the gastrointestinal tract and rapidly converted to NAD+ in tissues throughout the body. NAD+ then fuels hundreds of metabolic processes, including energy production in mitochondria, DNA repair by PARP enzymes, and activation of sirtuins. This comprehensive cellular support addresses aging at its most fundamental level.

Works Best With:

Resveratrol (enhances sirtuin activation)
CoQ10 (complementary mitochondrial support)
B Vitamins (NAD+ metabolism cofactors)

Dosage Information

Per Chew25 mg
Small Dogs (<25 lbs)25 mg (1 chew)
Medium Dogs (25-50 lbs)50 mg (2 chews)
Large Dogs (>50 lbs)75 mg (3 chews)

Timing: Best given with a meal for optimal absorption

NMN is highly bioavailable and begins working within hours of consumption. Consistent daily supplementation provides cumulative benefits.

Safety Profile

NMN has been extensively studied for safety in multiple animal models and human clinical trials. It is well-tolerated even at high doses with no significant adverse effects reported. NMN is naturally present in small amounts in foods like broccoli, cabbage, and avocados.

Research & Citations

Scientific studies supporting the benefits of NMN

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

Mills KF, Yoshida S, Stein LR, et al.

Cell Metabolism, 2016

Demonstrated that NMN administration improved energy metabolism, physical activity, and insulin sensitivity in aged mice.

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NAD+ Repletion Improves Mitochondrial and Stem Cell Function and Enhances Life Span in Mice

Zhang H, Ryu D, Wu Y, et al.

Science, 2016

Showed that boosting NAD+ levels improved mitochondrial function and extended healthspan in mouse models.

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Nicotinamide Mononucleotide Supplementation Reverses Vascular Dysfunction and Oxidative Stress with Aging in Mice

de Picciotto NE, Gano LB, Johnson LC, et al.

Aging Cell, 2016

NMN supplementation restored vascular function and reduced oxidative stress markers in aged mice.

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Effect of Oral Administration of Nicotinamide Mononucleotide on Clinical Parameters and Nicotinamide Metabolite Levels in Healthy Japanese Men

Irie J, Inagaki E, Fujita M, et al.

Endocrine Journal, 2020

Human clinical trial demonstrating safety and efficacy of oral NMN supplementation.

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Give Your Dog the Gift of Longevity

NMN is just one of the powerful ingredients in Pawdagen's comprehensive longevity formula.