Trans-Resveratrol: The Longevity Activator
Trans-Resveratrol activates sirtuins, the "longevity genes" that slow aging and support optimal health in aging dogs.
Why does my dog age so quickly?
Aging is driven by the progressive decline of cellular repair mechanisms. Sirtuins are the master regulators of these repair processes. As dogs age, sirtuin activity declines, accelerating aging and disease.
This manifests as:
- Accelerated AgingVisible signs of aging appear earlier
- Reduced VitalityLess energy and enthusiasm
- Cognitive DeclineMemory loss and reduced mental sharpness
Sirtuin Activity by Age
With and without Trans-Resveratrol supplementation
*Based on sirtuin activity studies in aging mammals
Activating the Longevity Genes
Trans-Resveratrol directly activates sirtuins, restoring the cellular repair mechanisms that slow aging and support optimal health.
Sirtuin Activation
Trans-Resveratrol directly activates sirtuins (especially SIRT1 and SIRT3), the master regulators of cellular repair and longevity.
NAD+ Restoration
Sirtuins require NAD+ as a cofactor. Trans-Resveratrol supports NAD+ levels, enabling optimal sirtuin function.
Cellular Repair
Activated sirtuins upregulate DNA repair, mitochondrial function, and autophagy—slowing aging at the cellular level.
How Trans-Resveratrol Works
Sirtuin Activation Cascade
Trans-Resveratrol binds to sirtuins and activates them through allosteric mechanisms. Once activated, sirtuins deacetylate proteins involved in DNA repair, mitochondrial function, and stress resistance. This cascade of activation is the foundation of trans-resveratrol's anti-aging effects.
Mitochondrial Optimization
SIRT3 activation improves mitochondrial function and ATP production. This is crucial for brain health, as the brain consumes enormous amounts of energy. Optimized mitochondria support cognitive function and reduce age-related cognitive decline.
Stress Resistance & Autophagy
Activated sirtuins enhance cellular stress resistance and autophagy—the cell's ability to remove damaged components. This cellular "housekeeping" is essential for maintaining health and slowing aging.
Backed by Research
Safety Profile
Plant Polyphenol (Not Grape-Derived)
- ✓Plant polyphenol extract sourced from non-grape sources—completely safe for dogs
- ✓Generally well-tolerated in dogs at therapeutic doses
- ✓Supports natural antioxidant pathways and cellular defense mechanisms
- ✓No toxicity observed even at high doses in safety studies
- ✓Safe for long-term supplementation supporting cardiovascular and cellular health
- ✓Naturally supports healthy aging at the molecular level
- ✓Compatible with all other Pawdagen ingredients for comprehensive longevity support
All Pawdagen ingredients are selected for safety, efficacy, and compatibility with your dog's health.
Synergistic Ingredients
Trans-Resveratrol + NMN
Longevity powerhouse. Both activate sirtuins and support NAD+ for comprehensive anti-aging support.
Trans-Resveratrol + Curcumin
Anti-inflammatory and longevity synergy. Both reduce inflammation and activate cellular repair pathways.
Trans-Resveratrol + CoQ10
Mitochondrial optimization. Both support sirtuin activation and mitochondrial energy production.
Trans-Resveratrol + Lion's Mane
Brain longevity. Trans-Resveratrol activates sirtuins while Lion's Mane stimulates NGF for cognitive support.