Curcumin: The Anti-Inflammatory Powerhouse
Curcumin is the active compound in turmeric that powerfully reduces inflammation and supports brain health in aging dogs.
Why does my dog have chronic pain?
Chronic inflammation is the root cause of most age-related diseases in dogs. As dogs age, inflammatory markers increase dramatically, affecting joints, brain, heart, and overall health.
This manifests as:
- Joint Pain & StiffnessDifficulty moving, especially after rest
- Brain InflammationCognitive decline and memory loss
- Overall DeclineReduced vitality and accelerated aging
Inflammatory Markers Over Time
With Curcumin supplementation
*Based on clinical studies with Curcumin supplementation
Powerful Anti-Inflammatory Support
Curcumin is one of nature's most powerful anti-inflammatory compounds, blocking inflammatory pathways at the molecular level.
NF-κB Inhibition
Curcumin blocks NF-κB, the master inflammatory switch, reducing inflammatory cytokines throughout the body.
Joint Support
Reduces joint inflammation and supports cartilage health, improving mobility and reducing pain.
Brain Protection
Crosses the blood-brain barrier to reduce neuroinflammation, protecting cognitive function and memory.
How Curcumin Works
NF-κB Pathway Inhibition
Curcumin is one of the most potent NF-κB inhibitors known. NF-κB is the master regulator of inflammatory gene expression. By blocking NF-κB, curcumin reduces the production of inflammatory cytokines like TNF-α, IL-6, and IL-1β throughout the body.
Antioxidant Defense
Curcumin is a potent antioxidant that neutralizes free radicals and reactive oxygen species (ROS), which drive inflammation. This dual mechanism—blocking inflammatory pathways AND neutralizing oxidative stress—makes curcumin exceptionally effective.
Blood-Brain Barrier Penetration
Unlike most anti-inflammatory compounds, curcumin crosses the blood-brain barrier to reduce neuroinflammation. This is crucial for cognitive aging prevention, as neuroinflammation is a primary driver of dementia and cognitive decline.
Backed by Research
Safety Profile
Purified Anti-Inflammatory Extract
- ✓Highly purified plant extract with superior bioavailability compared to raw turmeric
- ✓Supports natural inflammatory response without pharmaceutical side effects
- ✓Minimal gastrointestinal effects at recommended levels—well-tolerated by sensitive dogs
- ✓Naturally supports joint mobility and comfort without overstimulation
- ✓Safe for long-term supplementation in dogs with mobility concerns
- ✓No serious adverse effects at therapeutic doses
- ✓Compatible with other joint-support and antioxidant ingredients
All Pawdagen ingredients are selected for safety, efficacy, and compatibility with your dog's health.
Synergistic Ingredients
Curcumin + Trans-Resveratrol
Anti-inflammatory and antioxidant powerhouse. Both block inflammatory pathways for comprehensive inflammation control.
Curcumin + Ashwagandha
Inflammation and stress support. Curcumin reduces inflammation while Ashwagandha supports stress resilience.
Curcumin + Lion's Mane
Brain inflammation and growth. Curcumin reduces neuroinflammation while Lion's Mane stimulates NGF for cognitive support.
Curcumin + CoQ10
Anti-inflammatory and energy support. Curcumin reduces inflammation while CoQ10 powers cells for optimal function.