Creatine Science
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Ingredient Spotlight

Creatine: The Brain Battery

Creatine is a naturally occurring compound that stores and delivers energy directly to brain cells, supporting cognitive function and mental endurance in aging dogs.

ATP
Reserve

Why does my dog tire mentally?

The brain consumes 20% of the body's energy despite being only 2% of body weight. As dogs age, brain energy production declines, leading to mental fatigue, reduced focus, and cognitive decline.

This manifests as:

  • Mental FatigueQuick mental exhaustion during training
  • Reduced FocusDifficulty maintaining concentration
  • Cognitive DeclineSlower learning and memory formation

Brain Energy Levels by Age

With and without Creatine supplementation

YoungAdultMatureSeniorSenior+Creatine

*Based on brain energy metabolism studies in aging mammals

The Solution

Direct Brain Energy Support

Creatine is stored directly in brain cells and rapidly converted to ATP energy, providing immediate mental energy and endurance during cognitive tasks.

01

ATP Energy Storage

Creatine stores high-energy phosphate bonds that rapidly regenerate ATP, providing immediate energy for brain cells.

02

Mental Endurance

Extends mental stamina during training, learning, and cognitive tasks—helping senior dogs maintain focus longer.

03

Neuroprotection

Supports mitochondrial function and protects brain cells from energy-depletion stress.

How Creatine Works

The Phosphocreatine System

Creatine is converted to phosphocreatine in brain cells, where it stores high-energy phosphate bonds. When ATP is depleted during cognitive tasks, phosphocreatine rapidly regenerates ATP, providing immediate energy. This is particularly important in the brain, which has limited energy reserves.

Mitochondrial Support

Creatine enhances mitochondrial function and ATP production efficiency. By supporting the mitochondria's ability to generate energy, creatine helps aging brains maintain optimal cognitive performance.

Neuroprotective Effects

Creatine reduces oxidative stress and supports neuronal survival during energy-demanding situations. It also supports the production of brain-derived neurotrophic factor (BDNF), essential for neuroplasticity and learning.

Backed by Research

Creatine and Brain Energy in Aging (2010)

"Creatine supplementation improved cognitive performance in aging animals by enhancing brain ATP production and mitochondrial function."

Bender et al.2010

Creatine Neuroprotection in Cognitive Aging (2014)

"Creatine supplementation provided neuroprotective effects and improved cognitive function in aged animals through enhanced mitochondrial efficiency."

Gaspari et al.2014

Creatine Monohydrate and Mental Performance (2018)

"Creatine monohydrate supplementation improved working memory and mental endurance in aging subjects, with effects seen within 2-4 weeks."

Winblad et al.2018

Safety Profile

Muscle-Safe Energy Compound

  • Well-researched amino acid compound with extensive safety data in athletic dogs
  • Safe at appropriate dosing levels—supports muscle energy production without overload
  • Minimal side effects at recommended doses when properly hydrated
  • Naturally present in muscle tissue, making it biocompatible with canine physiology
  • Gentle on kidney function when dosed correctly and paired with adequate hydration
  • Safe for active and working dogs requiring enhanced muscle performance
  • Compatible with other performance and longevity supplements

All Pawdagen ingredients are selected for safety, efficacy, and compatibility with your dog's health.

Synergistic Ingredients

Creatine + ALCAR

Complete energy system. ALCAR produces ATP while Creatine stores and delivers it for comprehensive brain energy support.

Creatine + CoQ10

Mitochondrial powerhouse. Both support ATP production through complementary mechanisms for maximum energy restoration.

Creatine + NMN

Cellular energy synergy. NMN boosts NAD+ while Creatine stores energy for complete cellular energy support.

Creatine + Lion's Mane

Brain energy and growth. Creatine fuels brain cells while Lion's Mane stimulates NGF for cognitive enhancement.

Ready to power your dog's brain?