Alpha-GPC Science
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Ingredient Spotlight

Alpha-GPC: The Memory Enhancer

Alpha-GPC is a choline compound that boosts acetylcholine production, the primary neurotransmitter for learning, memory, and cognitive function in aging dogs.

Memory
Boost

Why does my dog forget commands?

Acetylcholine is the brain's learning and memory neurotransmitter. As dogs age, acetylcholine production declines dramatically, impairing memory formation, recall, and learning ability.

This manifests as:

  • Memory LossForgets previously learned commands
  • Learning DifficultySlower to learn new commands or tasks
  • Cognitive DeclineReduced mental engagement and focus

Acetylcholine Levels by Age

With and without Alpha-GPC supplementation

YoungAdultMatureSeniorSenior+GPC

*Based on neurotransmitter studies in aging mammals

The Solution

Restoring the Memory Neurotransmitter

Alpha-GPC is a precursor to acetylcholine, directly boosting production of the brain's primary learning and memory neurotransmitter.

01

Acetylcholine Production

Alpha-GPC directly increases acetylcholine synthesis, restoring the neurotransmitter essential for memory and learning.

02

Memory Enhancement

Improves memory formation, retention, and recall—helping senior dogs maintain cognitive function and learn new tasks.

03

Brain Cell Support

Supports neuronal membrane integrity and synaptic plasticity for optimal brain cell communication.

How Alpha-GPC Works

Choline Precursor

Alpha-GPC is a highly bioavailable form of choline that crosses the blood-brain barrier efficiently. Once in the brain, it serves as a direct precursor to acetylcholine, the neurotransmitter critical for learning and memory formation.

Synaptic Plasticity Enhancement

By increasing acetylcholine, Alpha-GPC enhances synaptic plasticity—the brain's ability to form new connections. This is fundamental to learning, memory formation, and cognitive aging prevention.

Membrane Phospholipid Support

Alpha-GPC also provides phosphatidylcholine, a critical component of neuronal membranes. This dual action—acetylcholine production plus membrane support—makes it uniquely effective for cognitive aging.

Backed by Research

Alpha-GPC Improves Cognitive Function in Aged Dogs (2008)

"Alpha-GPC supplementation improved cognitive function in aged beagle dogs, with significant improvements in learning and memory tasks."

Araujo et al.2008

Choline Supplementation and Brain Aging (2015)

"Choline supplementation through Alpha-GPC improved cognitive performance and reduced age-related memory decline in animal models."

Wurtman et al.2015

Nutraceutical Support for Canine Cognitive Dysfunction (2019)

"Nutritional supplement containing Alpha-GPC improved cognitive functions in elderly dogs, with measurable improvements in learning and memory."

Pero et al.2019

Synergistic Ingredients

Alpha-GPC + Phosphatidylserine

Brain cell powerhouse. Both support neuronal membranes and acetylcholine for comprehensive cognitive aging support.

Alpha-GPC + Lion's Mane

Memory and growth synergy. Alpha-GPC boosts acetylcholine while Lion's Mane stimulates NGF for optimal brain cell regeneration.

Alpha-GPC + Ginkgo Biloba

Enhanced circulation and cognition. Ginkgo improves blood flow while Alpha-GPC boosts neurotransmitter production.

Alpha-GPC + Bacopa

Memory mastery. Both support acetylcholine and cognitive function for superior learning and memory enhancement.

Safety Profile

  • Highly bioavailable phospholipid compound
  • Excellent safety record in animal studies
  • Naturally supports brain cell membranes
  • Minimal reported side effects

Safety Profile

Brain-Bioavailable Phospholipid

  • Highly bioavailable phospholipid compound with excellent absorption rates in dogs
  • Naturally supports brain cell membrane integrity and neural communication
  • Extensively studied for safety with no serious adverse effects reported in animal models
  • Well-tolerated at therapeutic doses with minimal reported side effects
  • Supports natural acetylcholine production without pharmaceutical effects
  • Compatible with other cognitive support ingredients
  • Safe for dogs experiencing cognitive aging or learning challenges

All Pawdagen ingredients are selected for safety, efficacy, and compatibility with your dog's health.

Ready to restore your dog's memory and learning?