The Complete Dog Supplements Guide
Every ingredient in Pawdagen explained — what it does, why it's included, and how it works with the other 13 compounds in the formula. This is the most comprehensive dog supplement reference on the internet.
The Four Pillars of Canine Cellular Aging
Aging in dogs is not a single process — it's four simultaneous cellular failures. Effective supplementation must address all four. Pawdagen's 14 ingredients are organized around these four pillars.
NAD+ Restoration
NAD+ declines 50% by age 7–8 in dogs. Restoring it activates cellular repair, DNA maintenance, and longevity signaling.
Cognitive & Brain Health
Seven synergistic compounds targeting neuroplasticity, neurotransmitter production, and cerebrovascular health.
Inflammaging Control
Chronic low-level inflammation accelerates aging across all systems. These three compounds target it from different molecular angles.
Mitochondrial Function
Mitochondrial dysfunction is a hallmark of aging. These compounds restore ATP production and protect mitochondrial integrity.
All 14 Ingredients — Explained
Click any ingredient to read the full science page with published research citations, mechanism of action, and dosing rationale.
NMN (Nicotinamide Mononucleotide)
Restores NAD+ levels that decline 50% by age 7–8 in dogs. NAD+ is the master regulator of cellular energy, DNA repair, and longevity signaling.
CoQ10 (Coenzyme Q10)
Powers mitochondrial ATP production — the energy currency of every cell. CoQ10 also acts as a potent antioxidant protecting mitochondrial membranes from oxidative damage.
Lion's Mane Mushroom
Stimulates NGF (Nerve Growth Factor) production, promoting neuroplasticity and new brain cell growth. The only natural compound known to regenerate myelin sheaths.
Curcumin 95%
Potent COX-2 inhibitor that reduces chronic inflammaging at the cellular level. The 95% extract is 10x more bioavailable than standard turmeric powder.
Trans-Resveratrol
Activates SIRT1 and SIRT3 longevity genes — the same pathways studied in caloric restriction research. Works synergistically with NMN to amplify NAD+ benefits.
Bacopa Monnieri
Enhances memory consolidation and learning by increasing dendritic branching. Shown to reduce anxiety and improve cognitive function in aging mammals.
Ashwagandha (KSM-66)
Reduces cortisol-driven inflammation and supports adrenal function. KSM-66 is the most clinically studied ashwagandha extract with 22 published studies.
Alpha-GPC
The most bioavailable form of choline — the precursor to acetylcholine, the primary neurotransmitter for memory and muscle control. Critical for dogs with cognitive decline.
Phosphatidylserine
Maintains the integrity of neuronal cell membranes and supports signal transduction. Shown to improve cognitive function and reduce cortisol in aging mammals.
Ginkgo Biloba
Improves cerebral blood flow and oxygen delivery to the brain. Contains flavonoids and terpenoids that protect neurons from oxidative damage.
Creatine Monohydrate
Buffers ATP production during high-demand periods. Supports muscle maintenance and has emerging evidence for neuroprotective effects in aging mammals.
ALCAR (Acetyl-L-Carnitine)
Transports fatty acids into mitochondria for energy production. Also crosses the blood-brain barrier to support neuronal energy metabolism and acetylcholine synthesis.
L-Theanine
Promotes alpha brain wave activity — the state of calm, focused alertness. Works synergistically with other cognitive ingredients to reduce anxiety without sedation.
L-Tyrosine
Precursor to dopamine, norepinephrine, and thyroid hormones. Supports mood, motivation, and cognitive performance — especially important for working and active breeds.
Key Ingredient Synergies
Pawdagen is not 14 separate supplements — it's a formula engineered around synergistic interactions. These are the most important pairings.
The Longevity Stack
NMN raises NAD+ levels. Resveratrol activates the sirtuin enzymes that use NAD+ to perform cellular repair. Together they're significantly more effective than either alone.
The Brain Stack
Lion's Mane stimulates NGF for new neuron growth. Alpha-GPC provides the acetylcholine needed for those neurons to communicate. Structural growth + functional support.
The Anti-Inflammaging Stack
Both target the NF-κB inflammatory pathway but through different mechanisms. Curcumin inhibits COX-2. Resveratrol inhibits upstream inflammatory signaling. Dual-pathway coverage.
The Mitochondrial Stack
ALCAR transports fatty acids into mitochondria. CoQ10 powers the electron transport chain that converts those fatty acids into ATP. Transport + combustion.
The Calm Cognition Stack
Bacopa improves memory consolidation over time. L-Theanine promotes alpha brain waves for calm, focused alertness. Long-term memory + immediate calm focus.
The Cellular Energy Stack
NMN restores NAD+ for cellular energy regulation. CoQ10 directly powers mitochondrial ATP production. Together they address cellular energy from two different angles.
Frequently Asked Questions About Dog Supplements
All 14 Ingredients. One Daily Chew.
Pawdagen combines every ingredient on this page at clinically relevant doses — engineered for synergy, not just ingredient lists.